| Identification | Back Directory | [Name]
OM99-2 | [CAS]
314266-76-7 | [Synonyms]
OM99-2
EVNL-PSI-AAEF
InSolution? OM99-2
InSolution OM99-2 - CAS 314266-76-7 - Calbiochem
GLU-VAL-ASN-(2R,4S,5S)-5-AMINO-*4-HYDROXY-2,7-DIMET
glu-val-asn-[(2r,4s,5s)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-ala-glu-phe
[2-AMINOBENZOYL-GLY1]-GALANIN FRAGMENT (1-10)-LYS(RETRO-M-NITRO-TYR) AMIDE HUMAN
H-GLU-VAL-ASN-[(2R,4S,5S)-5-AMINO-4-HYDROXY-2,7-DIMETHYL-OCTANOYL]-ALA-GLU-PHE-OH
Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe >93% (HPLC), solid
[2-aminobenzoyl-gly1]-galanin fragment (1-10)-lys(retro-m-nitro-tyr) amide, human trifluoroacetate salt
OM99-2;[2-AMINOBENZOYL-GLY1]-GALANIN FRAGMENT (1-10)-LYS(RETRO-M-NITRO-TYR) AMIDE, HUMAN TRIFLUOROACETATE SALT
L-Phenylalanine, L-α-glutamyl-L-valyl-L-asparaginyl-(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl-L-alanyl-L-α-glutamyl- | [Molecular Formula]
C41H64N8O14 | [MDL Number]
MFCD03452932 | [MOL File]
314266-76-7.mol | [Molecular Weight]
892.99 |
| Chemical Properties | Back Directory | [Boiling point ]
1346.5±65.0 °C(Predicted) | [density ]
1.289±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [form ]
solid | [pka]
3.48±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2]. OM99-2 has the potential for the research of the Alzheimer's disease[3]. | [Biological Activity]
Cell permeable: no''Primary Target
human brain memapsin 2''Product does not compete with ATP.''Reversible: no''Target Ki: 1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D | [IC 50]
BACE1 | [References]
[1] Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. DOI:10.1021/ja000300g
[2] Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. DOI:10.3389/fnmol.2020.00137
[3] Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. DOI:10.1080/713609213
[4] Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422. DOI:10.1021/ja0304493 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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