| Identification | Back Directory | [Name]
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine | [CAS]
314771-76-1 | [Synonyms]
Afatinib-1
Afatinib INT
Afatinib IMpurity B
afatinib impurities140
Afatinib intermediate D
Intermediates of sunitinib
Afatinib Impurity 1 ABCDEFGHJKL
3-furanyl]oxy]-4,6-quinazolinediamine
Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl
N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)...
S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4
4-N-(3-chloro-4-fluorophenyl)-7-[(3S)-oxolan -3-yl]oxyquinazoline-4,6-diamine
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamie
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl) aMino-6-aMinoquinazoline
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine
(S)-N-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine
6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[[(S)-tetrahydro-3-furanyl]oxy]quinazoline
4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-amine-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine ISO 9001：2015 REACH | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C18H16ClFN4O2 | [MDL Number]
MFCD18642925 | [MOL File]
314771-76-1.mol | [Molecular Weight]
374.8 |
| Chemical Properties | Back Directory | [Boiling point ]
559.0±50.0 °C(Predicted) | [density ]
1.473±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated, Heated) | [form ]
Solid | [pka]
5.89±0.30(Predicted) | [color ]
Light Yellow to Light Beige |
| Hazard Information | Back Directory | [Uses]
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | [Synthesis]
To a solution of 4-(3-chloro-4-fluorophenyl)amino-6-nitro-7-[[(S)-tetrahydro-3-furanyl]oxy]-
quinazoline (1.34 g, 3.31 mmol) and ammonium chloride (496 mg, 9.27 mmol)
in anhydrous DMF (22 mL), Raney nickel [1.5 mL, 50 % (w/v) in water] was added to
the reaction mixture and stirred under an atmosphere of hydrogen at 40 °C for 2 h. After
2 h the reaction was diluted with EtOH (10 mL), filtered through diatomaceous earth
and washed with a large excess of EtOH. The residue was concentrated under reduced
pressure and purified by column chromatography eluting with CHCl3/MeOH (95:5) to
give 6 as a viscous brown oil (950 mg, 77 %). |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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