| Identification | Back Directory | [Name]
OPIPRAMOL | [CAS]
315-72-0 | [Synonyms]
G-33040
GR-33040
Nisidana
Opramidol
OPIPRAMOL
NSC 169867
N-[3-[4-(2-hydroxyethyl)piperazino]propyl]iminostilbene
4-(3-(DIBENZ(B,F)AZEPIN-5-YL)PROPYL)-1-PIPERAZINEETHANOL
1-Piperazineethanol, 4-3-(5H-dibenzb,fazepin-5-yl)propyl-
4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol | [EINECS(EC#)]
206-254-0 | [Molecular Formula]
C23H29N3O | [MDL Number]
MFCD00865455 | [MOL File]
315-72-0.mol | [Molecular Weight]
363.5 |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
100-1010C | [Boiling point ]
494.88°C (rough estimate) | [density ]
1.0920 (rough estimate) | [refractive index ]
1.6500 (estimate) | [storage temp. ]
-20°C Freezer | [solubility ]
Acetonitrile: slightly soluble; Chloroform: slightly soluble; Methanol: slightly soluble | [form ]
neat | [pka]
pKa 8(H2O,t =25,I=0.01(NaCl)) (Uncertain) | [color ]
Light yellow to yellow | [BRN ]
627076 | [Major Application]
forensics and toxicology
veterinary | [InChI]
1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2 | [InChIKey]
YNZFUWZUGRBMHL-UHFFFAOYSA-N | [SMILES]
OCCN(CC1)CCN1CCCN2C(C=CC=C3)=C3C=CC4=C2C=CC=C4 |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
Antidepressant; antipsychotic | [Originator]
Insidon,Geigy,W. Germany,1962 | [Definition]
ChEBI: 2-[4-[3-(11-benzo[b][1]benzazepinyl)propyl]-1-piperazinyl]ethanol is a dibenzoazepine. | [Manufacturing Process]
A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.
| [Therapeutic Function]
Antidepressant, Antipsychotic |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
22-50/53 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
1 | [RTECS ]
TL8750000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1 |
|
| Company Name: |
China Langchem Inc.
|
| Tel: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|