| Identification | Back Directory | [Name]
TC-DAPK 6 | [CAS]
315694-89-4 | [Synonyms]
CS-1003
TC-DAPK 6
DAPK inhibitor
TCDAPK6;DAPK INHIBITOR
2-(2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone
5(4H)-Oxazolone, 2-(2-phenylethenyl)-4-(3-pyridinylmethylene)-
(4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
2-(2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone TC-DAPK 6 | [Molecular Formula]
C17H12N2O2 | [MDL Number]
MFCD07278745 | [MOL File]
315694-89-4.mol | [Molecular Weight]
276.29 |
| Chemical Properties | Back Directory | [Boiling point ]
439.6±55.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 18.67 mg/mL (67.57 mM; Need ultrasonic and warming)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
3.44±0.12(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11+ | [InChIKey]
GFGMISOSPOPSHN-QCTDOKRBSA-N | [SMILES]
N1=C(OC(=O)\C\1=C/c3cnccc3)\C=C\c2ccccc2 |
| Hazard Information | Back Directory | [Uses]
TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC50=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP). | [References]
[1] Okamoto M, et al. Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J Med Chem. 2009 Nov 26;52(22):7323-7. DOI:10.1021/jm901191q |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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