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315702-75-1

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315702-75-1 Structure

315702-75-1 Structure
IdentificationBack Directory
[Name]

3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol
[CAS]

315702-75-1
[Synonyms]

KCC-07
3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
3-((4-(Pyridin-2-yl)thiazol-2-yl)amino)phenol
3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol
KCC07,BAI1,p53,inhibit,ADGRB1,anticancer,Inhibitor,DNA Alkylator/Crosslinker,MBD2,KCC-07,anti-proliferative,ADGR,KCC 07,brain-penetrant
[Molecular Formula]

C14H11N3OS
[MDL Number]

MFCD01121976
[MOL File]

315702-75-1.mol
[Molecular Weight]

269.32
Chemical PropertiesBack Directory
[storage temp. ]

4°C, protect from light
[solubility ]

Soluble in DMSO
Hazard InformationBack Directory
[Uses]

KCC 07 is a MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
[storage]

4°C, protect from light
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