| Identification | Back Directory | [Name]
2-Amino-1,3-benzenediol | [CAS]
3163-15-3 | [Synonyms]
o-aminoresorcinol
2-Aminoresorcinol
2-amino-1,3-benzenediol
2-aMinobenzene-1,3-diol
1,3-Benzenediol, 2-amino-
2-amino-1,3-dihydroxybenzene
6-BROMO-2,4-DIETHOXY-1-NITROBENZENE | [EINECS(EC#)]
926-781-6 | [Molecular Formula]
C6H7NO2 | [MDL Number]
MFCD00128992 | [MOL File]
3163-15-3.mol | [Molecular Weight]
125.13 |
| Chemical Properties | Back Directory | [Melting point ]
>200 °C (decomp) | [Boiling point ]
292.8±30.0 °C(Predicted) | [density ]
1.412±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [pka]
9.24±0.10(Predicted) | [Appearance]
Light brown to khaki Solid |
| Hazard Information | Back Directory | [Synthesis]
(1) 2-Nitroresorcinol (1.00 g, 6.45 mmol) was dissolved in ethanol (10 mL). 10% Pd/C catalyst (340 mg, 0.32 mmol) was added to the solution at room temperature and under hydrogen atmosphere and the reaction was stirred for 6 hours. Upon completion of the reaction, the insoluble material was removed by filtration and the solvent was subsequently removed by distillation under reduced pressure to afford the brown crystalline product 2-aminoresorcinol 779 mg in 97% yield. Melting point: 153-155 °C (decomposition).1H NMR (CD3OD/CDCl3 = 1/20, 400 MHz) δ: 6.37 (2H, d, J = 8 Hz), 6.54 (1H, t, J = 8 Hz). | [References]
[1] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0089
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 2186 - 2197
[3] Journal of Medicinal Chemistry, 1992, vol. 35, # 21, p. 3792 - 3802
[4] Patent: WO2005/54249, 2005, A1. Location in patent: Page/Page column 24
[5] European Journal of Medicinal Chemistry, 2010, vol. 45, # 9, p. 3531 - 3540 |
|
|