| Identification | Back Directory | [Name]
Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- | [CAS]
317318-97-1 | [Synonyms]
ChloroMethylthiazole
5-Chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole
4-[5-(Chloromethyl)-4-methyl-1,3-thiazol-2-yl]benzotrifluoride
5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-...
Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-
5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole | [Molecular Formula]
C12H9ClF3NS | [MDL Number]
MFCD03791173 | [MOL File]
317318-97-1.mol | [Molecular Weight]
291.72 |
| Chemical Properties | Back Directory | [Melting point ]
60-62° | [Boiling point ]
363.5±52.0 °C(Predicted) | [density ]
1.357±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Chloroform, Methanol | [form ]
Solid | [pka]
1.62±0.10(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
Intermediate in the production of GW 501516 and its derivatives | [Synthesis]
To a stirred solution of Intermediate 1 (8.2 g, 30 mmol) and triethylamine (6.07 g, 8.36 mL, 60 mmol) in anhydrous dichloromethane (120 mL) at 0 °C was slowly added methanesulfonyl chloride (5.49 g, 3.71 mL, 48 mmol). After 2 hours of reaction at 0°C, additional triethylamine (6 mmol) and methanesulfonyl chloride (4.8 mmol) were added. After 2 hours of reaction, thin layer chromatography (TLC, unfolding agent: hexane/ethyl acetate, 1:1) showed complete reaction. The reaction mixture was diluted with dichloromethane (120 mL) and washed sequentially with saturated sodium bicarbonate solution (2 x 240 mL) and water (2 x 240 mL), and the organic phase was dried, filtered, and concentrated to afford 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (8.0 g, 27 mmol, 90% yield) as a yellow solid. | [References]
[1] Patent: WO2004/785, 2003, A2. Location in patent: Page 43 |
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