| Identification | Back Directory | [Name]
3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)- | [CAS]
317844-33-0 | [Synonyms]
LY466195
LY-466195
LY 466195
LY466195,LY 466195
3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)- | [Molecular Formula]
C16H24F2N2O4 | [MDL Number]
MFCD09970604 | [MOL File]
317844-33-0.mol | [Molecular Weight]
346.37 |
| Hazard Information | Back Directory | [Uses]
LY-466195 is a selective and competitive GLUK5 receptor antagonist. LY-466195 antagonizes Kainate-induced currents with an IC50 value of 0.045 μM in rat dorsal root ganglion neurons. In HEK293 cells transfected with GLUK5, GLUK2/GLUK5, or GLUK5/GLUK66 receptors, LY466195 produces IC50 values of 0.08 μM, 0.34 μM, and 0.07 μM, respectively[1]. | [References]
[1] Brianne Weiss, et al. Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo. J Pharmacol Exp Ther. 2006 Aug;318(2):772-81. DOI:10.1124/jpet.106.101428 |
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