| Identification | Back Directory | [Name]
morclofone | [CAS]
31848-01-8 | [Synonyms]
morclofone
4'-Chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone
4'-chloro-3,5-dimethoxy-4-(2-morpholin-4-yl-ethoxy)-benzophenone
Methanone, (4-chlorophenyl)[3,5-dimethoxy-4-[2-(4-morpholinyl)ethoxy]phenyl]- | [EINECS(EC#)]
250-838-8 | [Molecular Formula]
C21H24ClNO5 | [MOL File]
31848-01-8.mol | [Molecular Weight]
405.87 |
| Hazard Information | Back Directory | [Originator]
Plausitin,Carlo Erba,Italy,1975 | [Definition]
ChEBI: Morclofone is a member of benzophenones. | [Manufacturing Process]
Sodium methoxide (1.2 g) in dimethylformamide (150 ml) was stirred with
3,5-dimethoxy-4'-chloro-4-hydroxybenzophenone (6 g) in dimethylformamide
(50 ml), for 2 hours at 120°C. The reaction mixture was then treated with β-
morpholinoethyl chloride (3.4 g) and heated for 1 hour at 140C, then
evaporated to dryness, and treated with water to give a solid material. The
mixture was filtered, washed and crystallized from cyclohexane to give 3,5-
dimethoxy-4'-chloro-4-(β-morpholinoethoxy)-benzophenone (6.5 g), MP 91°C
to 92°C. The product was then reacted at about 0°C with gaseous hydrogen
chloride in ether to give, after crystallization from isopropanol, the
corresponding hydrochloride which had a MP of 187.9°C. | [Therapeutic Function]
Antitussive |
|