| Identification | Back Directory | [Name]
MECLIZINE HYDROCHLORIDE (500 MG) | [CAS]
31884-77-2 | [Synonyms]
Antivert
Permesin
Meclizine hydrochloride
Meclizine Related CoMpound B
MECLIZINE HYDROCHLORIDE (500 MG)
MECLIZINE HYDROCHLORIDE MONOHYDRATE
Meclizine dihydrochloride monohydrate
1-[(4-Chlorophenyl)phenylMethyl]-4-[(3-Methylphenyl)Methyl]piperazine DiHydrochloride Hydrate | [EINECS(EC#)]
688-525-7 | [Molecular Formula]
C25H27ClN2.2ClH.H2O | [MDL Number]
MFCD00941489 | [MOL File]
31884-77-2.mol | [Molecular Weight]
481.892 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
210-213°C | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White | [Water Solubility ]
Insoluble in water. | [CAS DataBase Reference]
31884-77-2 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Antiemetic | [Uses]
For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness. | [Brand name]
Antivert (Pfizer). | [Originator]
Antivert,Roerig,US,1957 | [Definition]
ChEBI: Meclizine hydrochloride is a diarylmethane. | [Manufacturing Process]
32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This
solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The
solvent is evaporated and the residue is distilled under high vacuum. The
product of the condensation distills near 230°C at 2 mm Hg pressure and the
corresponding dihydrochloride melts at 217° to 224°C. | [Therapeutic Function]
Antinauseant | [General Description]
Meclizine hydrochloride,1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazinedihydrochloride monohydrate (Bonine, Antivert), is atasteless, white or slightly yellowish crystalline powder that is practically insoluble in water (1:1,000). It differs fromchlorcyclizine in having an N-m-methylbenzyl group inplace of the N-methyl group. Although it is a moderately potentantihistaminic, meclizine is used primarily as an antinauseantin the prevention and treatment of motion sicknessand in the treatment of nausea and vomiting associated withvertigo. |
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