| Identification | Back Directory | [Name]
4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID& | [CAS]
320-37-6 | [Synonyms]
4-Nitro-2-trifluoromethylbenzo
2-Carboxy-5-nitrobenzotrifluoride
2-TrifluoroMethyl-4-nitrobenzoic acid
4-Nitro-2-(trifluoromethyl)benzoic acid 97%
4-Nitro-2-(trifluoromethyl)benzoic acid,97% | [Molecular Formula]
C8H4F3NO4 | [MDL Number]
MFCD04039246 | [MOL File]
320-37-6.mol | [Molecular Weight]
235.12 |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
138-142 °C(lit.)
| [Boiling point ]
321.4±42.0 °C(Predicted) | [density ]
1.596±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Powder | [pka]
2.40±0.32(Predicted) | [color ]
White to off-white | [InChI]
1S/C8H4F3NO4/c9-8(10,11)6-3-4(12(15)16)1-2-5(6)7(13)14/h1-3H,(H,13,14) | [InChIKey]
BPCKZQCTLCTDST-UHFFFAOYSA-N | [SMILES]
OC(=O)c1ccc(cc1C(F)(F)F)[N+]([O-])=O |
| Questions And Answer | Back Directory | [Uses]
4-Nitro-2-(trifluoromethyl)benzoic acid is a carboxylic acid derivative, mainly used as a pharmaceutical and pesticide intermediate. |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Synthesis]
A mixture of 2-trifluoromethylbenzoic acid (1 eq.) and concentrated sulfuric acid (22 eq.) was placed in a mechanical stirrer under nitrogen protection and cooled to 0-5 °C in an ice bath. Subsequently, fuming nitric acid (9.8 eq.) was slowly added dropwise at the same temperature for 60 minutes. After completion of the dropwise addition, the ice bath was removed and the reaction mixture was allowed to continue stirring at room temperature for 120 minutes. Upon completion of the reaction, the mixture was slowly poured into ice water and stirred at room temperature for 60 minutes. The suspension was collected by filtration and washed with cold water to give the crude 4-nitro-2-trifluoromethylbenzoic acid. To remove the regional isomers, the crude product was recrystallized from water to give the final pure product in 45% yield. The melting point range was 137-142°C. | [References]
[1] Patent: WO2015/186137, 2015, A1. Location in patent: Page/Page column 17; 18
[2] J. Gen. Chem. USSR (Engl. Transl.), 1963, vol. 33, p. 2957 - 2960
[3] Zhurnal Obshchei Khimii, 1963, vol. 33, # 9, p. 3031 - 3035
[4] Patent: WO2005/51366, 2005, A2. Location in patent: Page/Page column 61
[5] Patent: WO2005/51366, 2005, A2. Location in patent: Page/Page column 61 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22-36-43 | [Safety Statements ]
26-36 | [WGK Germany ]
3
| [HS Code ]
29163990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Sens. 1 |
|
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
| Website: |
www.energy-chemical.com |
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