| Identification | Back Directory | [Name]
H-THR-PHE-ARG-GLY-ALA-PRO-OH | [CAS]
320347-28-2 | [Synonyms]
TFRGAP
PAR-3 (1-6) (HUMAN)
THR-PHE-ARG-GLY-ALA-PRO
H-THR-PHE-ARG-GLY-ALA-PRO-OH
THROMBIN RECEPTOR-LIKE 2 (1-6) (HUMAN)
PROTEINASE ACTIVATED RECEPTOR 3 (1-6) (HUMAN)
COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) (HUMAN)
L-Threonyl-L-phenylalanyl-L-arginylglycyl-L-alanyl-L-proline
L-Proline, L-threonyl-L-phenylalanyl-L-arginylglycyl-L-alanyl-
Coagulation Factor II Receptor-Like 2 (1-6) (huMan), Proteinase Activated Receptor 3 (1-6) (huMan), ThroMbin Receptor-Like 2 (1-6) (huMan), TFRGAP | [Molecular Formula]
C29H45N9O8 | [MDL Number]
MFCD02259583 | [MOL File]
320347-28-2.mol | [Molecular Weight]
647.72 |
| Chemical Properties | Back Directory | [storage temp. ]
-15°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [Sequence]
Thr-Phe-Arg-Gly-Ala-Pro |
| Hazard Information | Back Directory | [Uses]
PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110. | [References]
[1] Kaufmann, et al. Proteinase-activated receptors (PARs) - The PAR3 neo-N-terminal peptide TFRGAP interacts with PAR1. Regul. Pept. 125(1-3), 61-66 (2005). |
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