| Identification | Back Directory | [Name]
N-ACETYL-L-CYSTEINE METHYL ESTER | [CAS]
32381-28-5 | [Synonyms]
DACDM
NSC136019
NSC-136019
NSC 136019
AC-L-CYS-OME
(AC-CYS-OME)2
(Ac-L-Cys-OMe)2
N-Acetylcysteine methyl ester
(Ac-Cys-OMe)2 (Disulfide bond)
ACETYL-L-CYSTINE DIMETHYL ESTER
N-ACETYL-L-CYSTEINE METHYL ESTER
N,N'-Diacetylcystine dimethyl ester
N,N'-Diacetyl-L-cystine dimethyl ester
L-Cystine, N,N'-diacetyl-, 1,1'-dimethyl ester
Acetyl-L-cystine bis-methyl ester[Disulfide bond]
(2R)-2-(Acetylamino)-3-mercaptopropionic acid methyl ester
Acetyl-L-cystine bis-methyl ester[Disulfide bond]≥ 99% (TLC)
(2R,2'R)-Dimethyl 3,3'-disulfanediylbis(2-acetamidopropanoate)
3,3'-Dithiobis[(R)-2-(acetylamino)propanoic acid methyl] ester | [Molecular Formula]
C12H20N2O6S2 | [MDL Number]
MFCD00083613 | [MOL File]
32381-28-5.mol | [Molecular Weight]
352.43 |
| Chemical Properties | Back Directory | [Melting point ]
77-81 °C | [Boiling point ]
584.5±50.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
DMSO: Soluble: = 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml | [pka]
13.89±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
Dimethyl diacetyl cystinate is a derivative of the oxidized dimeric form of cysteine L-cystine (Item No. 31727).1 It inhibits UVB radiation-induced NF-κB nuclear translocation in and IL-1α secretion from HaCaT cells when used at concentrations of 50 or 100 µM. Dimethyl diacetyl cystinate (10 µg/ml) decreases proliferation and IFN-γ and IL-2 secretion in a co-culture of lymphocytes isolated from BALB/c mice and irradiated splenocytes isolated from C57BL/10J mice.2 Subconjunctival administration of dimethyl diacetyl cystinate (8 µg/animal) reduces corneal glutathione (GSH) levels and increases corneal allograft survival in mice.WARNING This product is not for human or veterinary use. | [Chemical Properties]
White powder | [References]
[1] MANABU KITAZAWA. Intracellular redox regulation by a cystine derivative suppresses UV-induced NF-κB activation[J]. FEBS Letters, 2002, 526 1-3: 106-110. DOI: 10.1016/s0014-5793(02)03152-6
[2] JUN YAMADA. Major histocompatibility complex semi-matching improves murine corneal allograft survival under oxidative macrophage dominancy.[J]. Transplantation, 2007, 84 7: 899-907. DOI: 10.1097/01.tp.0000284731.22247.a3 |
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Sigma-Aldrich
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