| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-formyl- (9CI) | [CAS]
3240-35-5 | [Synonyms]
Mafenide USP RC A
4-sulfamoylbenzaldehyde
p-Sulfamoylbenzaldehyde
benzenesulfonamide, 4-formyl-
4-methanoylbenzenesulfonamide
4-FORMYLBENZENESULFONAMIDE,95%
Benzenesulfonamide, 4-formyl- (9CI)
Mafenide Impurity 1 (Mafenide USP RC A) | [Molecular Formula]
C7H7NO3S | [MDL Number]
MFCD03196508 | [MOL File]
3240-35-5.mol | [Molecular Weight]
185.2 |
| Questions And Answer | Back Directory | [Synthesis]
mixture of (4-(N-acetamidosulfonyl)phenyl)methylene diacetate intermediate compound 61 (4.55 mmol, 1.5 g), H₂SO₄ (0.3 mL), H₂O (1.5 mL), and EtOH (4.8 mL) was stirred in a sealed tube at 90°C for 3 hours. The brown solution was then cooled and the solvent was removed under reduced pressure. The residue was partitioned between EtOAc and water (3 x 10 mL). The organic layer was washed with 5% K₂CO₃ aqueous solution and water. The solution was then dried with anhydrous MgSO₄, filtered, and the solvent was reduced under reduced pressure to give the title compound 4-Benzenesulfonamide, 4-formyl- (9CI). Yield: 677 mg, 80%. ¹H NMR (400 MHz, DMSO-d⁶) δ 10.1 (¹H, s) 8.18 (²H, d, J = 8.4 Hz), 7.99 (²H, d, J + 8.8 Hz), 4.96 (¹H, s), 4.91 (¹H). Figure 4. Synthetic route of Benzenesulfonamide, 4-formyl- (9CI). |
| Chemical Properties | Back Directory | [Melting point ]
118-120 °C | [Boiling point ]
392.7±44.0 °C(Predicted) | [density ]
1.424±0.06 g/cm3(Predicted) | [storage temp. ]
2-30°C | [pka]
9.76±0.10(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C7H7NO3S/c8-12(10,11)7-3-1-6(5-9)2-4-7/h1-5H,(H2,8,10,11) | [InChIKey]
PCPUKVSTMLHXQF-UHFFFAOYSA-N | [SMILES]
C1(S(N)(=O)=O)=CC=C(C=O)C=C1 |
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