| Chemical Properties | Back Directory | [Boiling point ]
229.2±13.0 °C(Predicted) | [density ]
1.029±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [pka]
6.54±0.11(Predicted) | [Appearance]
White to yellow Solid-Liquid Mixture |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: 3-Aminopyridine (2.0 g, 21.2 mmol), acetonitrile (4.36 g, 106 mmol) and 10% Pd/C catalyst (0.2 g) were dissolved in methanol (20 mL). The reaction mixture was stirred at 25°C under hydrogen atmosphere for 16 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using 5-10% methanol/dichloromethane as eluent to afford N-ethylpyridin-3-amine (0.7 g). | [References]
[1] Organic Letters, 2004, vol. 6, # 26, p. 4977 - 4980
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 2, p. 293 - 304
[3] Patent: US2016/96835, 2016, A1. Location in patent: Paragraph 0088; 0089 |
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