| Identification | Back Directory | [Name]
rac-Febrifugine Dihydrochloride | [CAS]
32434-42-7 | [Synonyms]
Febrifugine dihydrochloride
rac-Febrifugine Dihydrochloride
3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride | [Molecular Formula]
C16H19N3O3 | [MDL Number]
MFCD27978373 | [MOL File]
32434-42-7.mol | [Molecular Weight]
301.34 |
| Chemical Properties | Back Directory | [Melting point ]
220-222 °C (decomp) | [storage temp. ]
-20°C | [solubility ]
H2O: soluble15mg/mL, clear | [form ]
powder | [color ]
off-white to gray to brown | [Optical Rotation]
[α]/D 10 to 15°, c = 1 in H2O | [Water Solubility ]
H2O: 15mg/mL, clear | [InChI]
1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1 | [InChIKey]
SNTOTCUGCWLHEZ-KKJWGQAZSA-N | [SMILES]
O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
rac-Febrifugine dihydrochloride is the salt of Febrifugine, a bioactive constituent of a Chinese medicinal herb that is characterized by its therapeutic activity regarding malaria, cancer, fibrosis and inflammatory diseases. | [Biochem/physiol Actions]
Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity. | [IC 50]
Plasmodium |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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