| Identification | Back Directory | [Name]
2-(3,6-dinitro-9H-carbazol-9-yl)-N,N-diethylethan-1-amine | [CAS]
324780-02-1 | [Synonyms]
CBLC000 trifluoroacetate
9H-Carbazole-9-ethanamine, N,N-diethyl-3,6-dinitro-
2-(3,6-dinitro-9H-carbazol-9-yl)-N,N-diethylethan-1-amine | [Molecular Formula]
C18H20N4O4 | [MDL Number]
MFCD01542971 | [MOL File]
324780-02-1.mol | [Molecular Weight]
356.38 |
| Chemical Properties | Back Directory | [Boiling point ]
490.2±45.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
9.99±0.25(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
CBLC000 is a potent inhibitor of FACT (facilitates chromatin transcription) complex th at activates p53 and suppresses NF-kB without genotoxicity. CBLC000 induces chromatin trapping of FACT both in vitro and in vivo. CBLC000 exhibits brad anticancer activity. CBLC000 analog clinical candidate CBL0137 decreases self-renewal of GBM stem cells (GSC). |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Specs
|
| Tel: |
+31 15 251 8111 |
| Website: |
www.specs.net |
|