| Identification | Back Directory | [Name]
Benzeneethanol, beta-amino-3-fluoro-, (betaS)- (9CI) | [CAS]
325152-98-5 | [Synonyms]
(S)-2-AMino-2-(3-fluorophenyl)ethanol
(2S)-2-amino-2-(3-fluorophenyl)ethanol
Benzeneethanol, β-amino-3-fluoro-, (βS)-
(S)-2-amino-2-(3-fluorophenyl)ethan-1-ol
(2S)-2-AMino-2-(3-fluorophenyl)ethan-1-ol
Benzeneethanol, beta-amino-3-fluoro-, (betaS)- (9CI) | [Molecular Formula]
C8H10FNO | [MDL Number]
MFCD09256370 | [MOL File]
325152-98-5.mol | [Molecular Weight]
155.17 |
| Chemical Properties | Back Directory | [Melting point ]
101-103 °C | [Boiling point ]
286.3±25.0 °C(Predicted) | [density ]
1.208±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
12.40±0.10(Predicted) | [Appearance]
White to yellow Solid | [InChI]
InChI=1/C8H10FNO/c9-7-3-1-2-6(4-7)8(10)5-11/h1-4,8,11H,5,10H2/t8-/s3 | [InChIKey]
ZPXAEESIPIUPTJ-SBYBRXNCNA-N | [SMILES]
C1([C@H](N)CO)=CC=CC(F)=C1 |&1:1,r| |
| Hazard Information | Back Directory | [Uses]
Used as an intermediate in laboratory research. | [Preparation]
(Rs,2S)-N-((tert-butyldimethylsilyloxy)-1-(4-fluorophenyl)ethyl)-2-methylpropane-2-sulfinamide (0.280 g, 0.749 mmol) was dissolved in MeOH (10 mL) and then HCl/MeOH (4 M, 2.0 mL) was added. The solution was stirred at room temperature for 3 h. After that, the solvent was removed under vacuum and the residue neutralized with saturated NaHCO3 (20 mL). The mixture was extracted with CH2Cl2/MeOH and the organic phases dried (Na2SO4) and concentrated to obtained (S)-2-Amino-2-(3-fluorophenyl)ethanol.
| [Reactions]
By coupling an amine group to a carboxyl group, (S)-2-Amino-2-(3-fluorophenyl)ethanol could be employed to synthesize (S)-N-{1-(3-fluorophenyl)-2-hydroxyethyl}-4-{5-methyl-2-(phenylamino)pyrimidin-4-yl}-1H-pyrrole-2-carboxamide..
 | [Synthesis]
(S)-2-Amino-2-(3-fluorophenyl)ethanol can be prepared by the amination reaction of 1-Ethenyl-3-fluorobenzene and ammonia water. | [References]
[1] Tetrahedron Asymmetry, 2011, vol. 22, # 3, p. 329 - 337 |
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SynAsst Chemical.
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Wuxi AppTec
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Mirro Chemical Co.,Ltd.
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