| Identification | Back Directory | [Name]
1-((2,5-dichlorophenyl)sulfonyl)-1H-benzo[d]imidazole | [CAS]
326901-92-2 | [Synonyms]
WDR5-IN-6
1-[(2,5-dichlorophenyl)sulfonyl]-1H-benzimidazole
1H-Benzimidazole, 1-[(2,5-dichlorophenyl)sulfonyl]-
1-((2,5-dichlorophenyl)sulfonyl)-1H-benzo[d]imidazole | [Molecular Formula]
C13H8Cl2N2O2S | [MDL Number]
MFCD00828171 | [MOL File]
326901-92-2.mol | [Molecular Weight]
327.19 |
| Chemical Properties | Back Directory | [Boiling point ]
525.7±60.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-0.28±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
WDR5-IN-6 is a WDR5 inhibitor, targeting to WBM site. WDR5-IN-6 inhibits cell proliferation of neuroblastoma cell lines with potent anti-tumor activity. WDR5-IN-6 shows high synergy with OICR-9429 (HY-16993), a WDR5 inhibitor targeting to WIN site. WDR5-IN-6 can be used for reasearch in neuroblastoma[1]. | [References]
[1] Han QL, et al. Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol Sin. 2023 Apr;44(4):877-887. DOI:10.1038/s41401-022-00999-z |
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