| Identification | Back Directory | [Name]
Benzaldehyde, 4-hydroxy-3,5-dimethoxy-, 2-(8-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone | [CAS]
327031-30-1 | [Synonyms]
Benzaldehyde, 4-hydroxy-3,5-dimethoxy-, 2-(8-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone | [Molecular Formula]
C19H18N6O3 | [MOL File]
327031-30-1.mol | [Molecular Weight]
378.39 |
| Hazard Information | Back Directory | [Uses]
LY2023-001 is a potent G2019S LRRK2 inhibitor with an IC50 of 12.9 nM. LY2023-001 formed stable hydrogen bonds with Glu1948, and Ala1950 in the G2019S LRRK2 protein[1]. | [References]
[1] Shuoyan Tan, et al. Identification of novel LRRK2 inhibitors by structure-based virtual screening and alchemical free energy calculation. Phys Chem Chem Phys. 2024 Jul 24;26(29):19775-19786. DOI:10.1039/d4cp01762e |
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