| Identification | Back Directory | [Name]
TCY-NH2 | [CAS]
327177-34-4 | [Synonyms]
TCY-NH2
M.W. 739.87 C40H49N7O7
trans-Cinnamoyl-YPGKF-NH2
TRANS-CINNAMOYL-YPGKF-AMIDE
trans-Cinnamoyl-YPGKF-NH2, tcY-NH2
TRANS-CINNAMOYL-TYR-PRO-GLY-LYS-PHE-NH2
trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-amide trifluoroacetate salt
L-Phenylalaninamide, N-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-L-tyrosyl-L-prolylglycyl-L-lysyl- | [Molecular Formula]
C40H49N7O7 | [MDL Number]
MFCD06798369 | [MOL File]
327177-34-4.mol | [Molecular Weight]
739.86 |
| Hazard Information | Back Directory | [Uses]
tcY-NH2 does not cause aggregation but blocks aggregation caused by receptor-activating peptide analogs (GY-NH2, AY-NH2), and thrombin without affecting ADP-mediated aggregation. | [in vivo]
tcY-NH2 (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology[3].
tcY-NH2 (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4+ Tregs within the draining lymph nodes in burn injury mice model [4].
tcY-NH2 (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice[6].
| Animal Model: | Brain death (BD) rat model[3] | | Dosage: | 0.6 mg/kg for a single dose | | Administration: | Tail vein injection for a single dose | | Result: | Reduced blood platelet activation and hepatic platelet accumulation.
Attenuated the inflammatory response and apoptosis in the livers.
Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD).
|
| Animal Model: | Burn injury model of C57BL/6 N mice[4] | | Dosage: | 0.6 mg/kg for a single dose | | Administration: | Intraperitoneal injection | | Result: | Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis.
|
| Animal Model: | BALB/c mice[6] | | Dosage: | 40 ng/kg for a single dose | | Administration: | Intrapleural injection | | Result: | Abolished the number of rolling and adhering neutrophils on the vessel wall.
Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice.
|
| [IC 50]
PAR4 | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|