| Identification | Back Directory | [Name]
Picotamide | [CAS]
32828-81-2 | [Synonyms]
g137
PICOTAMIDE
N,N’-Bis(3-Pyridinylmethyl)-4-Me
n,n’-bis(3-picolyl)-4-methoxyisophthalamide
4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid
4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide
4-methoxy-N,N'-bis(3-pyridylmethyl)isophthaldiamide
Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)-
n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide
4-METHOXY-N,N'-BIS(3-PYRIDINYLMETHYL)-1,3-BENZENEDICARBOXAMIDE
n,n’-bis(3-pyridinylmethyl)-4-methoxy-1,3-benzenedicarboxamide
-1,3-Benzenedicarboxamide, N,N'-bis(3-pyridinylmethyl)-4-methoxy
1,3-Benzenedicarboxamide, 4-methoxy-N1,N3-bis(3-pyridinylmethyl)-
4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide | [EINECS(EC#)]
251-245-7 | [Molecular Formula]
C21H20N4O3 | [MDL Number]
MFCD00866792 | [MOL File]
32828-81-2.mol | [Molecular Weight]
376.41 |
| Chemical Properties | Back Directory | [Melting point ]
128-131℃ | [Boiling point ]
668.1±55.0 °C(Predicted) | [density ]
1.246±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming). | [form ]
White solid. | [pka]
13.31±0.46(Predicted) | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | [InChI]
1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27) | [InChIKey]
KYWCWBXGRWWINE-UHFFFAOYSA-N | [SMILES]
COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3 |
| Safety Data | Back Directory | [WGK Germany ]
2 | [RTECS ]
CZ2235500 | [Storage Class]
11 - Combustible Solids | [Toxicity]
LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976) |
| Hazard Information | Back Directory | [Description]
Picotamide is an unique antithrombotic agent which acts by selectively inhibiting
thromboxane synthesis and blocking platelet thromboxane receptors without affecting
prostaglandin synthesis. It is reported to be useful in the treatment of myocardial
infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis. | [Originator]
Manetti-Roberts (Beecham (Italy) | [Uses]
Keratolytic. | [Uses]
Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis. | [Definition]
ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides. | [Brand name]
Plactidil | [References]
Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85
Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439
Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77 |
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China Langchem Inc.
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0086-21-58956006 |
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Shaanxi Dideu Medichem Co. Ltd
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Energy Chemical
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Bide Pharmatech Ltd.
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