| Identification | Back Directory | [Name]
3-bromo-5-(4-bromothien-2-yl)-N-(5-chloro-2-hydroxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | [CAS]
328540-44-9 | [Synonyms]
3-bromo-5-(4-bromothien-2-yl)-N-(5-chloro-2-hydroxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | [Molecular Formula]
C18H8Br2ClF3N4O2S | [MOL File]
328540-44-9.mol | [Molecular Weight]
596.603 |
| Hazard Information | Back Directory | [Uses]
MG-T-19 is an effective TIM-3 inhibitor that can suppress the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9. MG-T-19 can increase the production of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood mononuclear cells (PBMCs) from healthy donors, and enhance the ability of PBMCs to inhibit the proliferation of Kasumi-1 cells (an acute myelogenous leukemia cell line)[1]. | [References]
[1] Abdel-Rahman S A, et al. Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints[J]. Science Advances, 2024, 10(42): eadq5540. DOI:10.1126/sciadv.adq5540 |
|
|