| Identification | Back Directory | [Name]
Col003 | [CAS]
328565-16-8 | [Synonyms]
Col003
Col003 >=98% (HPLC)
Benzaldehyde, 2-hydroxy-3-nitro-5-(phenylmethyl)- | [Molecular Formula]
C14H11NO4 | [MDL Number]
MFCD00852947 | [MOL File]
328565-16-8.mol | [Molecular Weight]
257.24 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 25 mg/mL (97.19 mM) | [form ]
Solid | [color ]
Light yellow to yellow | [InChI]
1S/C14H11NO4/c16-9-12-7-11(6-10-4-2-1-3-5-10)8-13(14(12)17)15(18)19/h1-5,7-9,17H,6H2 | [InChIKey]
RKJXVCLOGNLZOI-UHFFFAOYSA-N | [SMILES]
OC1=C(C=C(C=C1C=O)CC2=CC=CC=C2)[N+]([O-])=O |
| Hazard Information | Back Directory | [Description]
Col003 is a novel selective inhibitor of the interaction between Hsp47 and collagen, causing delayed procollagen secretion and inhibiting collagen accumulation in the ECM. | [Uses]
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM). Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by destabilizing the collagen triple helix. Col003 can be used for the investigation of fibrosis[1] | [IC 50]
HSP47: 1.8 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085. DOI:10.1074/jbc.M117.815936 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|