| Identification | Back Directory | [Name]
Acetamide, N-[4-[3-[(4-chlorophenyl)methylene]-2,3-dihydro-2-oxo-5-phenyl-1H-pyrrol-1-yl]phenyl]- | [CAS]
328998-77-2 | [Synonyms]
inS3-54-A26
Acetamide, N-[4-[3-[(4-chlorophenyl)methylene]-2,3-dihydro-2-oxo-5-phenyl-1H-pyrrol-1-yl]phenyl]- | [Molecular Formula]
C25H19ClN2O2 | [MOL File]
328998-77-2.mol | [Molecular Weight]
414.88 |
| Hazard Information | Back Directory | [Description]
inS3-54-A26 is a novel inhibitor of the DNA-binding domain (DBD) of STAT3, suppressing tumor growth, metastasis and STAT3 target gene expression in vivo. | [Uses]
inS3-54-A26 is a STAT3 inhibitor. inS3-54-A26 has a toxic IC50 of 4.0 μM for non-cancerous lung fibroblasts[1]. | [References]
[1] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. DOI:10.1038/onc.2015.215 |
|
|