| Identification | Back Directory | [Name]
Benzaldehyde, 4-hydroxy-3-nitro-, 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone | [CAS]
329227-30-7 | [Synonyms]
L82
DNA ligase inhibitor
(E)-4-chloro-5-(2-(4-hydroxy-3-nitrobenzylidene)hydrazinyl)pyridazin-3-ol
(Z)-4-chloro-5-(2-(4-hydroxy-3-nitrobenzylidene)hydrazinyl)pyridazin-3-ol
Benzaldehyde, 4-hydroxy-3-nitro-, 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone | [Molecular Formula]
C11H8ClN5O4 | [MDL Number]
MFCD16916185 | [MOL File]
329227-30-7.mol | [Molecular Weight]
309.67 |
| Chemical Properties | Back Directory | [density ]
1.71±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 33.33 mg/mL (107.63 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.41±0.35(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
L82 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). L82 shows anti-proliferative activity to breast cancer cells[1][2]. | [References]
[1] Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39. DOI:10.1016/j.dnarep.2017.10.002
[2] Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-77. DOI:10.1158/0008-5472.CAN-07-6636 |
|
|