| Identification | Back Directory | [Name]
ethyl 1-acetylcyclopropanecarboxylate | [CAS]
32933-03-2 | [Synonyms]
thyl 1-acetylcyclopropanecarboxylate
ethyl 1-acetylcyclopropanecarboxylate
Ethyl 1-acetylcyclopropane-1-carboxylate
1-Acetyl-cyclopropanecarboxylic acid ethyl ester
1-acetyl-1-cyclopropanecarboxylic acid ethyl ester
Cyclopropanecarboxylic acid, 1-acetyl-, ethyl ester | [EINECS(EC#)]
628-471-3 | [Molecular Formula]
C8H12O3 | [MDL Number]
MFCD00480999 | [MOL File]
32933-03-2.mol | [Molecular Weight]
156.18 |
| Chemical Properties | Back Directory | [Boiling point ]
42-44 °C(Press: 2 Torr) | [density ]
1.139±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [Appearance]
Colorless to light yellow Liquid | [InChI]
InChI=1S/C8H12O3/c1-3-11-7(10)8(4-5-8)6(2)9/h3-5H2,1-2H3 | [InChIKey]
DISZFIFAESWGBI-UHFFFAOYSA-N | [SMILES]
C1(C(C)=O)(C(OCC)=O)CC1 |
| Hazard Information | Back Directory | [Uses]
ethyl 1-methyl cyclopropanecarboxylate is an important pharmaceutical intermediate used in the addition of cyclopropane. | [Synthesis]
Step 1) Synthesis of ethyl 1-acetylcyclopropanecarboxylate: To a solution of ethyl 3-oxobutanoate (26 g, 200 mmol) in acetone (500 mL) was added potassium carbonate (82.8 g, 600 mmol) followed by 1,2-dibromoethane (45.12 g, 240 mmol). The reaction mixture was refluxed for 24 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography with an eluent ratio of 1:50 (v/v) ethyl acetate/hexane to afford the target compound ethyl 1-acetylcyclopropanecarboxylate as a colorless oil (18.7 g, 60% yield). Mass spectrum (ESI, cation mode) m/z: 157 (M+1); 1H NMR (400 MHz, CDCl3) δ: 1.25-1.29 (t, J=7.2 Hz, 3H), 1.45 (s, 4H), 2.45 (s, 3H), 4.18-4.20 (q, 2H). | [References]
[1] Tetrahedron Letters, 2005, vol. 46, # 4, p. 635 - 638
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004, vol. 43, # 2, p. 420 - 422
[3] Tetrahedron Asymmetry, 2010, vol. 21, # 5, p. 631 - 635
[4] Journal of Organic Chemistry, 2011, vol. 76, # 8, p. 2807 - 2813
[5] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983, vol. 19, # 6, p. 644 - 650 |
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Sigma-Aldrich
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