| Identification | Back Directory | [Name]
3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride | [CAS]
329349-20-4 | [Synonyms]
1-(3,6-dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol dihydrochloride | [Molecular Formula]
C19H22Br2ClN3O | [MDL Number]
MFCD00276492 | [MOL File]
329349-20-4.mol | [Molecular Weight]
503.66 |
| Hazard Information | Back Directory | [Description]
BAI1 is an allosteric inhibitor of Bax channel activation. It binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation. It also selectively inhibits Bax-dependent apoptosis and is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release. | [Uses]
BAI1 hydrochloride is a selective apoptosis factor BAX allosteric inhibitors. BAI1 hydrochloride binds BAX and allosterically inhibits its activation. BAI1 hydrochloride has the potential to be used in the study of BAX dependent cell death-mediated diseases[1]. | [storage]
Desiccate at RT | [References]
[1] Garner TP, et al. Small-molecule allosteric inhibitors of BAX. Nat Chem Biol. 2019 Apr;15(4):322-330. DOI:10.1038/s41589-018-0223-0 |
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BOC Sciences
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https://www.bocsci.com |
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R&D Systems, Inc
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18003437475 18003437475 |
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www.rndsystems.com |
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