| Identification | Back Directory | [Name]
TN-16 | [CAS]
33016-12-5 | [Synonyms]
TN-16
Nsc 239274
TN-16, 10 mM in DMSO
3-(ANILINOETHYLIDENE)-5-BENZYLPYRROLIDINE-2,4-DIONE
3-(1-ANILINOETHYLIDENE)-5-BENZYLPYRROLIDINE-2,4-DIONE
TN-16,TN16,TN 16,inhibit,Microtubule/Tubulin,Inhibitor
5-Benzyl-3-[1-(phenylamino)ethylidene]pyrrolidine-2,4-dione
2,4-Pyrrolidinedione, 3-(1-anilinoethylidene)-5-benzyl- (8ci)
3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione
2,4-Pyrrolidinedione, 3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-
2,4-Pyrrolidinedione, 3-(1-(phenylamino)ethylidene)-5-(phenylmethyl)- (9ci) | [Molecular Formula]
C19H18N2O2 | [MDL Number]
MFCD02684017 | [MOL File]
33016-12-5.mol | [Molecular Weight]
306.36 |
| Chemical Properties | Back Directory | [Melting point ]
182～185℃ | [Boiling point ]
532.7±50.0 °C(Predicted) | [density ]
1.249±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥17mg/mL | [form ]
powder | [pka]
10.53±0.40(Predicted) | [color ]
white to tan | [InChI]
1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13- | [InChIKey]
KWSXUGYAGMSUTN-LGMDPLHJSA-N | [SMILES]
C\C(Nc1ccccc1)=C2\C(=O)NC(Cc3ccccc3)C2=O |
| Hazard Information | Back Directory | [Uses]
A novel synthetic inhibitor of microtubule formation which binds to the colchicine site. It prevents the stabilization of microtubules in taxol-treated cells. Blocks the cell cycle in M-phase. | [Biological Activity]
3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16)a tenuazonic acid derivativeis a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase. It is a colchicine site binding agent and a powerful autophagy flux inhibitor th at could be used as a conventional autophagy inhibitor with anti-cancer potential in pre-clinical trials.''Inhibitor of microtubule assembly''TN-16 is a synthetic compound th at blocks the assemblyand promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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