| Identification | Back Directory | [Name]
6-chloro-2-mercaptoquinazolin-4(3H)-one | [CAS]
33017-85-5 | [Synonyms]
6-chloro-2-mercaptoquinazolin-4(3H)-one
6-chloro-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
6-Chloro-2,3-dihydro-2-thioxo-4(1H)-quinazolinone | [Molecular Formula]
C8H5ClN2OS | [MDL Number]
MFCD00631491 | [MOL File]
33017-85-5.mol | [Molecular Weight]
212.66 |
| Hazard Information | Back Directory | [Uses]
SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 μM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 μM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes[1]. | [References]
[1] Ozturk OK, et al. Quinazoline derivatives as novel bacterial sphingomyelinase enzyme inhibitors. Bioorg Chem. 2025 Jan;154:108079. DOI:10.1016/j.bioorg.2024.108079 |
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