| Identification | Back Directory | [Name]
3-HYDROXY-2-PHENYLPYRIDINE | [CAS]
3308-02-9 | [Synonyms]
2-phenyl-3-pyridino
2-PHENYL-3-PYRIDINOL
2-PHENYL-PYRIDIN-3-OL
3-Pyridinol, 2-phenyl-
2-Phenyl-3-hydroxypyridine
3-HYDROXY-2-PHENYLPYRIDINE
1,4-Benzenediamine,2,7-dibromo-
3-HYDROXY-2-PHENYLPYRIDINE ISO 9001：2015 REACH
4-N-(2-bromophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine | [Molecular Formula]
C11H9NO | [MDL Number]
MFCD00731184 | [MOL File]
3308-02-9.mol | [Molecular Weight]
171.2 |
| Chemical Properties | Back Directory | [Melting point ]
205 °C | [Boiling point ]
320 °C | [density ]
1.169±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
8.23±0.10(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Tetrahedron, 48, p. 8117, 1992 DOI: 10.1016/S0040-4020(01)80481-6 | [Synthesis]
To a stirred solution of 2-iodo-3-hydroxypyridine (5.0 g, 22.624 mmol) in benzene (50 ml) was added phenylboronic acid (3.03 g, 24.85 mmol) and 2M Na2CO3 solution (20 mL) sequentially at 25 °C. The reaction system was protected and degassed with argon for 15 min. Tetrakis(triphenylphosphine)palladium (Pd(PPh3)4, 1.3 g, 5 mol%) was then added and degassing continued for 10 minutes. The reaction mixture was heated to reflux for 4 hours. After completion of the reaction, it was cooled to room temperature, water was added and extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by solvent milling with methyl tert-butyl ether (MTBE)/dichloromethane (DCM) mixture to give 3-hydroxy-2-phenylpyridine (3.2 g).LCMS detection showed a molecular ion peak of 172 (M + H). | [References]
[1] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 175; 178; 179 |
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| Company Name: |
Struchem Co., Ltd.
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| Telephone: |
0512-63009836 18994340901 |
| Website: |
http://www.beidapharma.com |
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