| Identification | Back Directory | [Name]
3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine | [CAS]
330819-85-7 | [Synonyms]
3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine
5H-Cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine, 6,7-dihydro-2-(methylthio)- | [Molecular Formula]
C10H11N3S2 | [MOL File]
330819-85-7.mol | [Molecular Weight]
237.34 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2mg/mL; DMSO: 20mg/mL; PBS (pH 7.2): insolube | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
VU0029251 is a partial antagonist of metabotropic glutamate receptor 5 (mGluR5; Ki = 1.07 μM).1 It inhibits calcium mobilization induced by glutamate in HEK293 cell membranes expressing rat mGluR5 (IC50 = 1.7 μM). | [Uses]
VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM). VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC50: 1.7 μM)[1]. | [storage]
Store at -20°C | [References]
1. Rodriguez, A.L., Grier, M.D., Jones, C.K., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity Mol. Pharmacol. 78(6),1105-1123(2010). |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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