| Identification | Back Directory | [Name]
Alloc-Val-Ala-OH | [CAS]
330970-70-2 | [Synonyms]
Alloc-Val-Ala-OH
((Allyloxy)carbonyl)-L-valyl-L-alanine
L-Alanine, N-[(2-propen-1-yloxy)carbonyl]-L-valyl-
(S)-2-((S)-2-(Allyloxycarbonylamino)-3-methylbutanamido)propanoic acid
(2S)-2-[(2S)-3-methyl-2-{[(prop-2-en-1-yloxy)carbonyl]amino}butanamido]propanoic acid | [Molecular Formula]
C12H20N2O5 | [MOL File]
330970-70-2.mol | [Molecular Weight]
272.3 |
| Chemical Properties | Back Directory | [Boiling point ]
498.3±40.0 °C(Predicted) | [density ]
1.155±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.49±0.10(Predicted) | [InChI]
InChI=1S/C12H20N2O5/c1-5-6-19-12(18)14-9(7(2)3)10(15)13-8(4)11(16)17/h5,7-9H,1,6H2,2-4H3,(H,13,15)(H,14,18)(H,16,17)/t8-,9-/m0/s1 | [InChIKey]
LOIWGNGKOQWZSA-IUCAKERBSA-N | [SMILES]
C(O)(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(OCC=C)=O |
| Hazard Information | Back Directory | [Description]
Alloc-Val-Ala-OH is a peptide linker with a terminal carboxylic acid group and an Alloc protecting group. The peptide chain can act as a cleavable linker in drug design, such as in antibody drug conjugates (ADC). The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Alloc group is stable to treatment with piperidine and TFA, and can be removed in neutral conditions with catalytic amounts of Pd(PPh3)4 in the presence of PhSiH3. This allows the allyl system to work orthogonality with the most common protecting groups. | [Uses]
N-Alloc-L-valyl-L-alanine is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. |
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| Company Name: |
xinguokeji Gold
|
| Telephone: |
13120711461 |
| Website: |
|
| Company Name: |
Shanghai GL Peptide Ltd.
|
| Telephone: |
+86-21-61263310 13764994101 |
| Website: |
www.chemicalbook.com/supplier/10480342/ |
| Company Name: |
GL Biochem (Shanghai) Ltd.
|
| Telephone: |
+86-021-61263370 +86-18901917034 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList212835/0_EN.htm |
| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
| Company Name: |
GL Biochem(Binhai) Ltd.
|
| Telephone: |
+86-021-61263370 15301650015 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList415547/0_EN.htm |
| Company Name: |
Binhai gill polypeptide co. LTD
|
| Telephone: |
021-61263389 13524856427 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList326362/0_EN.htm |
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