| Identification | Back Directory | [Name]
1,7-dibenzyl-8-((2-hydroxyethyl)thio)-3-methyl-3,7-dihydro-1H-purine-2,6-dione | [CAS]
331444-40-7 | [Synonyms]
1,7-dibenzyl-8-((2-hydroxyethyl)thio)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
1H-Purine-2,6-dione, 3,7-dihydro-8-[(2-hydroxyethyl)thio]-3-methyl-1,7-bis(phenylmethyl)- | [Molecular Formula]
C22H22N4O3S | [MOL File]
331444-40-7.mol | [Molecular Weight]
422.5 |
| Hazard Information | Back Directory | [General Description]
A purine-2,6-dione compound that targets the ATP-binding pocket of B-Raf and effectively inhibits the phosphorylation of MEK by wild-type B-Raf in cell-free in vitro kinase assays (IC50 = 1.7 μM and Ki, app = 106 nM with 100 μM ATP). Reported to be equally potent against the oncogenic V600E B-Raf mutant and exhibit much less activity against PI 3-Kγ (IC50 = 25 μM) and more than 50-fold selectivity over PAK1, GSK-3β, PAK4, MST1, and PIM1 (IC50 ≥100 μM). |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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