| Identification | Back Directory | [Name]
Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem | [CAS]
331684-05-0 | [Synonyms]
Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem
9H-Xanthen-9-one, 4-(1H-imidazol-1-ylmethyl)-1-nitro- | [Molecular Formula]
C17H11N3O4 | [MDL Number]
MFCD04974139 | [MOL File]
331684-05-0.mol | [Molecular Weight]
321.29 |
| Chemical Properties | Back Directory | [Boiling point ]
619.8±55.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 25mg/mL | [form ]
solid | [pka]
6.16±0.12(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
A potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC50 = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.
A potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC50 = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM). | [General Description]
A potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC50 = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 μM). | [Biochem/physiol Actions]
Primary TargetP450 arom. |
|
| Company Name: |
Merck Millipore
|
| Telephone: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|