| Identification | Back Directory | [Name]
CHROMECEPTIN | [CAS]
331859-86-0 | [Synonyms]
94G6
CHROMECEPTIN
Chromeceptin, 10 mM in DMSO
2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene
94G6, 2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene
2-Amino-7-(dimethylamino)-4-(3-(trifluoromethyl)phenyl)-4H-chromene-3-carbonitrile
4H-1-Benzopyran-3-carbonitrile, 2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C19H16F3N3O | [MDL Number]
MFCD00815850 | [MOL File]
331859-86-0.mol | [Molecular Weight]
359.35 |
| Chemical Properties | Back Directory | [Melting point ]
199-200 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
497.2±45.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
H2O: <2mg/mL | [form ]
solid | [pka]
4.23±0.70(Predicted) | [color ]
yellow to brown | [Water Solubility ]
H2O: <2mg/mL
DMSO: >20mg/mL |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals. |
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