| Identification | Back Directory | [Name]
1-[2-(4-methylphenoxy)ethyl]-2-[(2-phenoxyethyl)sulfanyl]-1H-benzimidazole | [CAS]
331948-99-3 | [Synonyms]
1-[2-(4-methylphenoxy)ethyl]-2-(2-phenoxyethylsulfanyl)benzimidazole
1-[2-(4-methylphenoxy)ethyl]-2-[(2-phenoxyethyl)sulfanyl]-1H-benzimidazole | [Molecular Formula]
C24H24N2O2S | [MOL File]
331948-99-3.mol | [Molecular Weight]
404.525 |
| Hazard Information | Back Directory | [Biological Activity]
MEPB is a modulator of the activation function-2 (AF-2) of the androgen receptor (AR)increasing AR co-repressor binding. MEPB specifically binds the BF3 pocket of the androgen receptor where it modulates binding of co-regulators to the AF2 domain. MEPB was found to rescue degeneration in a mouse model of spinal bulbar muscular atrophya motor neuron disease caused by toxic gain of function of the androgen receptor. |
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