| Identification | Back Directory | [Name]
Acetamide, N-(4-acetylphenyl)-2-[[4-phenyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]- | [CAS]
332376-42-8 | [Synonyms]
Antitrypanosomal agent 8
Acetamide, N-(4-acetylphenyl)-2-[[4-phenyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]- | [Molecular Formula]
C23H19N5O2S | [MOL File]
332376-42-8.mol | [Molecular Weight]
429.49 |
| Hazard Information | Back Directory | [Uses]
Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against Trypanosoma brucei with an IC50 value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC50=80.95 μM)[1]. | [References]
[1] Shaykoon MS, et al. Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives. Bioorg Chem. 2020 Jul;100:103933. DOI:10.1016/j.bioorg.2020.103933 |
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