| Identification | Back Directory | [Name]
N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide | [CAS]
333419-97-9 | [Synonyms]
WAY-339696
N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide
3-Quinolinecarboxamide, N-(3-bromophenyl)-1,2-dihydro-4-hydroxy-2-oxo- | [Molecular Formula]
C16H11BrN2O3 | [MOL File]
333419-97-9.mol | [Molecular Weight]
359.17 |
| Chemical Properties | Back Directory | [Boiling point ]
624.0±55.0 °C(Predicted) | [density ]
1.711±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.50±1.00(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
EGFR T790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR, targeting mutant EGFRT790M/L858R with IC50 of 56.8 μM. The anti-proliferative effect of EGFR T790M/L858R-IN-8 on cancer cell lines A549, A431, and NHI-H1975 is not significant[1]. | [References]
[1] Bai F, et al. Discovery of novel selective inhibitors for EGFR-T790M/L858R. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1365-70. DOI:10.1016/j.bmcl.2011.12.067 |
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| Company Name: |
Merck KGaA
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21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
PHARMEKS Ltd.
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+7 (495) 702-9648 |
| Website: |
www.pharmeks.com |
| Company Name: |
OTAVA chemicals
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416 305 9979 (Canada) |
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www.otavachemicals.com |
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