| Identification | Back Directory | [Name]
MK 436 | [CAS]
33450-08-7 | [Synonyms]
MK 436
1,2-Benzisoxazole, 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)- | [Molecular Formula]
C11H14N4O3 | [MDL Number]
MFCD01658964 | [MOL File]
33450-08-7.mol | [Molecular Weight]
250.25 |
| Hazard Information | Back Directory | [Uses]
MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America[1][2]. | [References]
[1] VandenHeuvel, et al. Identification of canine urinary metabolites of the antiprotozoal agent 3a, 4, 5, 6, 7, 7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1, 2-benzisoxazole. Journal of pharmaceutical sciences 69.11 (1980): 1288-1292. DOI:10.1002/jps.2600691115
[2] Jennings, et al. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77.5 (1983): 693-698. DOI:10.1016/0035-9203(83)90207-9 |
|
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|