| Identification | Back Directory | [Name]
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE | [CAS]
33458-26-3 | [Synonyms]
5118-36-5
EU-006731
NSC643910
SBB016167
NCI60_014903
A0951/0044480
Oprea1_330764
AURORA KA-3499
BUTTPARK 61\40-96
Maybridge1_006365
5-pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-4
ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin...
6-Methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
ethyl 4-methyl-6-phenyl-2-thioxo-3,6-dihydro-1H-pyrimidine-5-carboxylate
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
6-ME-4-PH-2-THIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
ethyl 4-methyl-6-phenyl-2-sulfanylidene-3,6-dihydro-1H-pyrimidine-5-carboxylate
Ethyl 6-methyl-4-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
Ethyl 6-methyl-4-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate
4-methyl-6-phenyl-2-thioxo-3,6-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
5-Pyrimidinecarboxylicacid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-thioxo-, ethyl ester
Pyrimidine-5-carboxilyc acid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-thioxo-, ethyl ester
Pyrimidine-5-carboxilyc acid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-t hione-, ethyl ester | [Molecular Formula]
C14H16N2O2S | [MDL Number]
MFCD00188414 | [MOL File]
33458-26-3.mol | [Molecular Weight]
276.35 |
| Chemical Properties | Back Directory | [Melting point ]
180 | [Boiling point ]
390.5±52.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [pka]
11.33±0.70(Predicted) | [InChIKey]
QMFBVGUFEGVPNG-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process middle. | [Synthesis]
In a 10-mL round-bottom flask equipped with a condenser, a mixture of the aromatic aldehyde (1 mmol), ethyl acetoacetate (1 mmol), urea or thiourea (1.5 mmol) and [Dsbim]Cl (0.0376 g, 10 mol%) was stirred at 80 °C, and the resulting mixture was kept under continuous stirring for lengths of time as specified in Table 3, with the progress of the reaction was followed by TLC. After completion of the reaction, the mixture was cooled to room temperature, and 3 mL of water was added. The ionic liquid was dissolved in water and filtered for separation of the crude product. The separated product was washed twice with water (2 9 3 mL). For recycling the catalysts, after the solid products were thoroughly washed with water, the water containing the ionic liquid (IL is soluble in water) was evaporated under reduced pressure, and the ionic liquid was recovered and reused. The solid product was purified by a recrystallization procedure in ethanol. All of the desired product(s) were characterized by comparison of their physical data with those of known compounds. Entry: 13 Product: 4m; Yield: 90% Mp: 208-210°C; Lit. Mp: 205-206 [23]°C |
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