| Identification | Back Directory | [Name]
BODIPY CYCLOPAMINE | [CAS]
334658-24-1 | [Synonyms]
BODIPY CYCLOPAMINE
[5-[(3,5-DiMethyl-2H-pyrrol-2-ylidene-κN)Methyl]-N-[6-[[2-[(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,2'R,11aS,11bR)-1,2,3,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3-hydroxy-3',6',10,11b-tetraMethylspiro[9H-benzo[a]fluorene-9,2'(4'H)-furo[3,2-b]pyridin]-4'-yl]ethyl]aMino]-6-oxohexyl]-1H-pyrrole-2-propanaMidato-κN1]difluoro-boron | [Molecular Formula]
C49H70BF2N5O4 | [MOL File]
334658-24-1.mol | [Molecular Weight]
841.919 |
| Chemical Properties | Back Directory | [Appearance]
Orange Powder | [Melting point ]
128-130°C | [storage temp. ]
Amber Vial, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Chloroform (Slightly) | [form ]
Solid | [color ]
Red to Brown | [Stability:]
Light Sensitive | [InChIKey]
CQPRECBXTRAUSE-NJOUNXRJNA-N | [SMILES]
C1CC2(C)C3CC4=C(C)C5(O[C@H]6CC(C)CN(CCNC(=O)CCCCCNC(=O)CCc7[n]8[B-](F)(F)[N+]9=C(C)C=C(C)C9=Cc8cc7)C6C5C)CCC4C3CC=C2C[C@H]1O |&1:11,59,r| |
| Hazard Information | Back Directory | [Chemical Properties]
Orange Powder | [Uses]
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The Bodipy-Cyclopamine is a fluorescent derivative of Cyclopamine that retains potency in Shh signaling inhibiti | [Uses]
It is a fluorescent derivative of Cyclopamine that retains potency in Shh signaling inhibition (IC50=150nM).
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