| Identification | Back Directory | [Name]
8-BROMO-2H-1-BENZOPYRAN-2-ONE | [CAS]
33491-30-4 | [Synonyms]
8-bromocoumarin
8-Bromochromen-2-one
8-BroMo-2H-chroMen-2-one
8-BROMO-2H-1-BENZOPYRAN-2-ONE
2H-1-Benzopyran-2-one, 8-bromo- | [EINECS(EC#)]
202-110-6 | [Molecular Formula]
C9H5BrO2 | [MDL Number]
MFCD09999238 | [MOL File]
33491-30-4.mol | [Molecular Weight]
225.04 |
| Chemical Properties | Back Directory | [Melting point ]
135-136 °C(Solv: methanol (67-56-1)) | [Boiling point ]
352.2±37.0 °C(Predicted) | [density ]
1.688±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature |
| Hazard Information | Back Directory | [Synthesis]
3-Bromo-2-hydroxybenzaldehyde (402 mg, 2.0 mmol) was used as starting material and dissolved in N-methylpyrrolidone (NMP, 5 mL). Subsequently, ethoxymethylene triphenylphosphine (765 mg, 2.2 mmol) was added to this solution. The reaction mixture was heated at 210 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently partitioned between water and ethyl acetate. The organic and aqueous layers were separated and the organic layer was dried with anhydrous magnesium sulfate (MgSO?). The product was purified by rapid column chromatography on silica gel (eluent ratio 2:1 hexane/ethyl acetate), resulting in 8-bromo-2H-1-benzopyran-2-one (116 mg, 26% yield) as a light beige solid. The mass spectrum (electrospray ionization, ES) showed m/e of 227.0 ([M + H]+). | [References]
[1] Patent: WO2007/118130, 2007, A2. Location in patent: Page/Page column 28-29
[2] Heterocycles, 2003, vol. 59, # 1, p. 217 - 224 |
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| Company Name: |
Cool Pharm, Ltd
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| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
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