| Identification | Back Directory | [Name]
7,8-Dihydro-14-hydroxy- normorphinone | [CAS]
33522-95-1 | [Synonyms]
EN 3169
(-)-Noroxymorphone
NoroxyMorphone HCl
Naloxone HCl Impurity
Naloxone EP Impurity A
Naltrexone EP Impurity B
Naltrexone EP Impuirty B
Naltrexone Impurity 6 Monomer
4-Hydroxydihydronormorphinone
Nor Oxymorphone (1.0mg/ml in DMSO)
Naltrexone hydrochloride iMpurity B
7,8-Dihydro-14-hydroxynormorphinone
LTREXONE HYDROCHLORIDE - IMPURITY B
Naloxone?Hydrochloride EP Impurity A
7,8-Dihydro-14-hydroxy- normorphinone
4,5α-Epoxy-3,14-dihydroxymorphinan-6-one
Noroxymorphone hydrochloride solution
Naloxone Impurity 7（Naloxone EP Impurity A）
(5α)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
(5α)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
(5a)-4,5-Epoxy-3,14-dihydroxy-morphinan-6-one
(5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-, (5a)-
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5α)-
Methanol(test NoroxymorphoneHCl,100μg/mLasfreebase)
Naloxone Hydrochloride Impurit Ⅰ:(5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one | [EINECS(EC#)]
251-561-5 | [Molecular Formula]
C16H17NO4 | [MDL Number]
MFCD08272693 | [MOL File]
33522-95-1.mol | [Molecular Weight]
287.32 |
| Chemical Properties | Back Directory | [Melting point ]
>265°C (dec.) | [Boiling point ]
552.1±50.0 °C(Predicted) | [density ]
1.54±0.1 g/cm3(Predicted) | [Fp ]
22℃ | [storage temp. ]
Controlled Substance, -20°C Freezer | [solubility ]
DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
9.20±0.40(Predicted) | [Stability:]
Hygroscopic | [InChI]
InChI=1/C16H17NO4/c18-9-2-1-8-7-11-16(20)4-3-10(19)14-15(16,5-6-17-11)12(8)13(9)21-14/h1-2,11,14,17-18,20H,3-7H2/t11-,14+,15+,16-/s3 | [InChIKey]
HLMSIZPQBSYUNL-RSBMUYHFNA-N | [SMILES]
O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])NCC[C@@]23C4=5)O |&1:1,6,15,20,r| |
| Hazard Information | Back Directory | [Description]
Noroxymorphone (Item No. 15903) is an analytical reference standard that is structurally categorized as an opioid. It is an active metabolite of oxycodone (Item No. ISO60148), noroxycodone (Item Nos. 15902 | 20407), and oxymorphone (Item No. ISO60171) that can be detected in plasma and urine.1,2,3 Noroxymorphone is also an immediate precursor in the synthesis of several opioids, including naltrexone (Item Nos. 15520 | ISO60192) and naloxone (Item Nos. 15594 | ISO60191).4 Noroxymorphone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications. | [Chemical Properties]
Off-White to Light Brown Solid | [Uses]
A metabolite of Naloxone and Naltrexone | [Definition]
ChEBI: Noroxymorphone is a member of phenanthrenes. | [References]
[1] CHAD M THOMPSON. Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 308 2: 547-554. DOI: 10.1124/jpet.103.058602
[2] MERJA KOKKI. Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine[J]. British journal of clinical pharmacology, 2016, 83 4: 791-800. DOI: 10.1111/bcp.13164
[3] TIMO KORJAMO. Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance.[J]. ACS Applied Energy Materials, 2012: 87. DOI: 10.3389/fphar.2011.00087
[4] BOJAN LALOVIC. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.[J]. ACS Applied Energy Materials, 2004: 447-454. DOI: 10.1124/dmd.32.4.447
[5] DR. BERNHARD GUTMANN. Batch- and Continuous-Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines—A Concise Synthesis of Noroxymorphone[J]. Chemistry - A European Journal, 2016, 22 30: 10393-10398. DOI: 10.1002/chem.201601902 |
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