| Identification | Back Directory | [Name]
Venturicidin | [CAS]
33538-72-6 | [Synonyms]
AaboMycin A2
Venturicidin
4,21-Dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one, 11-[(2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,18-tetramethyl-, (1R,5S,6R,8R,9E,11R,15E,17R)-
(1R,2E,7R,8E,10R,12R,13S,17R)-7-[(2R,4R,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-17-hydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4,6-dimethyl-7-oxononan-2-yl]-2,10,12,20-tetramethyl-14,21-dioxabicyclo[15.3.1]henicosa-2,8,19-trien-15-one | [Molecular Formula]
C40H66O10 | [MOL File]
33538-72-6.mol | [Molecular Weight]
706.95 |
| Chemical Properties | Back Directory | [Melting point ]
168-170°; mp 145-149° (ethyl acetate-petr ether) | [alpha ]
D +100° (c = 0.847 in chloroform) | [Boiling point ]
823.4±65.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
White to off-white solid. | [pka]
11.80±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Venturicidin B is a macrolide bacterial metabolite that has been found in Streptomyces. | [Uses]
The macrolide antibiotic Venturicidin B, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin A was originally isolated as an antifungal agent. | [Uses]
Venturicidin B is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. | [IC 50]
Macrolide | [References]
[1] H AKITA. Identity of aabomycin A with venturicidins.[J]. Agricultural and biological chemistry, 1990, 54 9: 2465-2466.
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