Identification | Back Directory | [Name]
Methyl 3-amino-6-methoxythieno[2,3-b]quinoline-2-carboxylate | [CAS]
335394-78-0 | [Synonyms]
Methyl 3-amino-6-methoxythieno[2,3-b]quinoline-2-carboxylate | [Molecular Formula]
C14H12N2O3S | [MOL File]
335394-78-0.mol | [Molecular Weight]
288.32 |
Chemical Properties | Back Directory | [Boiling point ]
501.3±45.0 °C(Predicted) | [density ]
1.409±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
4.76±0.40(Predicted) | [color ]
Light yellow to yellow |
Hazard Information | Back Directory | [Uses]
PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM). PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic[1]. | [References]
[1] Ren H, et al. Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1363-72. DOI:10.1152/ajprenal.00421.2014 |
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