| Identification | Back Directory | [Name]
N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-4-bromo-N-(3-dimethylamino-propyl)-benzamide | [CAS]
336115-72-1 | [Synonyms]
CK0106023
N-[1-(3-Benzyl-7-chloro-4-oxo-quinazolin-2-yl)propyl]-4-bromo-N-[3-(dimethylamino)propyl]benzamide
N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-4-bromo-N-(3-dimethylamino-propyl)-benzamide
Benzamide, 4-bromo-N-[1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]propyl]-N-[3-(dimethylamino)propyl]- | [Molecular Formula]
C30H32BrClN4O2 | [MDL Number]
MFCD10574781 | [MOL File]
336115-72-1.mol | [Molecular Weight]
595.96 |
| Hazard Information | Back Directory | [Uses]
CK0106023 is a potent and specific allosteric inhibitor of KSP with a Ki value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice[1][2]. | [References]
[1] You-Ling Fan. End-capped polyarylene polyethers, articles made therefrom and process for preparing such polyarylene polyethers. EP0106023B1. 1988 March 30.
[2] Sakowicz R, et al. Antitumor activity of a kinesin inhibitor. Cancer Res. 2004 May 1;64(9):3276-80. DOI:10.1158/0008-5472.can-03-3839 |
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