| Identification | Back Directory | [Name]
CLOTIAZEPAM | [CAS]
33671-46-4 | [Synonyms]
Rise
Rize
Rizen
Tienor
Clozan
Y 6047
Trecalmo
Veratran
CLOTIAZEPAM
Rize-13C,d3
Rizen-13C,d3
Clozan-13C,d3
CLOTIAZEPAM USP/EP/BP
Clotiazepam (1 mg/mL in Methanol)
5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
2h-thieno(2,3-e)(1,4)diazepin-2-one,1,3-dihydro-5-(o-chlorophenyl)-7-et
5-(o-Chlorophenyl)-7-ethyl-1-Methyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazep
2h-thieno(2,3e)(1,4)-diazepin-2-one,5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1
5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2h-thieno(2,3-e)(1,4)diazepi
5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2h-thieno(2,3-e)-1,4-diazepi
2h-thieno(2,3-e)(1,4)diazepin-2-one,1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-m
1-Methyl-5-o-chlorophenyl-7-ethyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one
5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno(2,3-e)-1,4-diazepin-2-one
5-(2-Chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one
5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno[2,3-e]-1,4-diazepin-2-one
2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
2H-Thieno(2,3-e)(1,4)diazepin-2-one, 1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-methyl-
2H-Thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
2H-Thieno[2,3-E]-1,4-diazepine-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
5-(o-Chlorophenyl)-7-ethyl-1-(Methyl-13C,d3)-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one
5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-(Methyl-13C,d3)-2H-thieno[2,3-e]-1,4-diazepin-2-one | [EINECS(EC#)]
251-627-3 | [Molecular Formula]
C16H15ClN2OS | [MDL Number]
MFCD00868176 | [MOL File]
33671-46-4.mol | [Molecular Weight]
318.82 |
| Chemical Properties | Back Directory | [Melting point ]
105-106° | [Boiling point ]
523.7±50.0 °C(Predicted) | [density ]
1.1625 (rough estimate) | [refractive index ]
1.6100 (estimate) | [solubility ]
DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml | [form ]
A crystalline solid | [pka]
2.36±0.20(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Originator]
Rize,Yoshitomi,Japan,1979 | [Uses]
A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to be
nzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor.
Controlled Substance. | [Definition]
ChEBI:Clotiazepam is an organic molecular entity. | [Manufacturing Process]
To a solution of 10 g of 2-N-methylaminoacetamido-3-o-chlorobenzoyl-5-ethylthiophene in 50 ml of pyridine are added 20 ml of benzene and 1.9 g of
acetic acid. The resulting mixture is refluxed with stirring for 10 hours in a
flask provided with a water-removing adaptor. The reaction mixture is
concentrated, and the residue is extracted with chloroform. The chloroform
layer is washed with water and then with a sodium hydrogen carbonate
solution, then dried over magnesium sulfate. The chloroform is distilled off
under reduced pressure, and toluene is added to the residue. Thus is
precipitated white crystalline-5-o-chlorophenyl-7-ethyl-1-methyl-1,2-dihydro-
3H-thieno-[2,3-e][1,4]diazepin-2-one, MP 105°C to 106°C. | [Therapeutic Function]
Tranquilizer |
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