| Chemical Properties | Back Directory | [Melting point ]
74-75 °C | [Boiling point ]
433.9±28.0 °C(Predicted) | [density ]
0.944±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Chloroform: soluble | [form ]
A solid | [pka]
4.78±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ～66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity[1]. | [Definition]
ChEBI: 9-hydroxyoctadecanoic acid is a hydroxyoctadecanoic acid that is octadecanoic acid (stearic acid) which has been substituted by a hydroxy group at position 9. It is a conjugate acid of a 9-hydroxyoctadecanoate. | [Biological Activity]
9-hydroxy Stearic acid is a hydroxy fatty acid and an active metabolite of 9-PAHSA .1,2 It is formed from 9-PAHSA by liver and pancreatic carboxyl ester lipases.2 9-hydroxy Stearic acid (5 μM) inhibits histone deacetylase 1 (HDAC1) in HT-29 colon cancer cell lysates.3 It inhibits the proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells when used at a concentration of 100 μM.1 | [IC 50]
HDAC1 | [References]
1.Calonghi, N., Cappadone, C., Pagnotta, E., et al.9-Hydroxystearic acid upregulates p21WAF1 in HT29 cancer cellsBiochem. Biophys. Res. Commun.314(1)138-142(2004)
2.Kolar, M.J., Kamat, S.S., Parsons, W.H., et al.Branched fatty acid esters of hydroxy fatty acids are preferred substrates of the MODY8 protein carboxyl ester lipaseBiochemistry55(33)4636-4641(2016)
3.Calonghi, N., Cappadone, C., Pagnotta, E., et al.Histone deacetylase 1: A target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancerJ. Lipid Res.46(8)1596-1603(2005)
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Alfa Chemistry
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1-516-6625404 |
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https://www.alfa-chemistry.com |
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