| Identification | Back Directory | [Name]
PROSTAGLANDINS F2ALPHA METHYL ESTER | [CAS]
33854-16-9 | [Synonyms]
PGF2a methyl
PGF2ALPHA-OME
13e,15s)-alph
pgf2methylester
Dinoprost methyl
dinoprostmethylester
pgf2-alphamethylester
Carboprost Impurity 9
prostaglandinf2methylester
PJDMFGSFLLCCAO-NVRZHKMMSA-N
prostaglandin F2A methyl ester
Prostaglandin F2α methyl ester
ProspaglandinF2alphamethylester
PROSTAGLANDIN F2ALPHA METHYL ESTER
PROSTAGLANDINS F2ALPHA METHYL ESTER
9,11,15-trihydroxy-,methylester,(5z,9-alpha,11-prosta-13-dien-1-oicacid
(5Z,13E,15S)-9α,11α,15-Trihydroxyprosta-5,13-dien-1-oic acid methyl ester
9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, METHYL ESTER
(5Z,9S,11S,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid methyl ester
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, methyl ester, (5Z,9α,11α,13E,15S)-
(Z)-Methyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoate | [EINECS(EC#)]
201-185-2 | [Molecular Formula]
C21H36O5 | [MDL Number]
MFCD00133790 | [MOL File]
33854-16-9.mol | [Molecular Weight]
368.51 |
| Chemical Properties | Back Directory | [Boiling point ]
418.83°C (rough estimate) | [density ]
1.0390 (rough estimate) | [refractive index ]
1.6120 (estimate) | [Fp ]
-9 °C | [storage temp. ]
−20°C | [solubility ]
DMF: 35 mg/ml; DMSO: 35 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.4 mg/ml | [InChIKey]
KRDFNHLEMLCWKD-GWSKAPOCSA-N | [SMILES]
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OCC |
| Hazard Information | Back Directory | [Uses]
Prostaglandin F2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF2α analog with more lipid solubility. Prostaglandin F2α methyl ester exhibits efficacy in maintaining the ocular hypotensive[1]. | [Definition]
ChEBI: PGF2alpha methyl ester is a prostanoid. | [Biochem/physiol Actions]
Constricts an isolated human smooth muscle; methyl ester form of prostaglandin F2α which is a luteolytic prostaglandin (induces parturition; pulmonary vasoconstrictor). | [in vivo]
Prostaglandin F2α methyl ester (1-10 μg for one eye, single dose) lowers the intraocular pressure (IOP) and reduces pupillary diameter in cats[1]. | Animal Model: | Cats[1] | | Dosage: | 1-10 μg | | Administration: | topically applied for one eye | | Result: | lowered the IOP and reduced pupillary diameter. |
| [References]
[1] Bito LZ. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res. 1984 Feb;38(2):181-94. DOI:10.1016/0014-4835(84)90102-7 |
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Sigma-Aldrich
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